Killing of Rat Adenocarcinoma 13762in Situby Adoptive Transfer of CD4+ Anti-tumor T Cells Requires Tumor Expression of Cell Surface MHC Class II Molecules
AB Frey, S Cestari - Cellular immunology, 1997 - Elsevier
CD4+ anti-tumor T cells reactive with rat adenocarcinoma 13762 kill tumorin vitroand cause
regression of tumorin vivo. The role of various host immune cells in CD4+ T-cell-mediated
tumor eliminationin vivowas investigated by adoptive transfer of anti-tumor T cell clones to
recipients that were selectively depleted of individual immune cell types. By these means,
macrophages and NK cells were found to be required for tumor killing. Depletion of host
CD4+ T cells, CD8+ T cells, or neutrophils was without effect on tumor elimination by anti …
regression of tumorin vivo. The role of various host immune cells in CD4+ T-cell-mediated
tumor eliminationin vivowas investigated by adoptive transfer of anti-tumor T cell clones to
recipients that were selectively depleted of individual immune cell types. By these means,
macrophages and NK cells were found to be required for tumor killing. Depletion of host
CD4+ T cells, CD8+ T cells, or neutrophils was without effect on tumor elimination by anti …
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